✦ LIBER ✦

Interpretation of the antitumour activity of some diacridines

✍ Scribed by P. G. Abdul-Ahad; G. A. Webb

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 769 KB
Volume: 21
Category: Article
ISSN: 0020-7608
DOI: 10.1002/qua.560210602

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✦ Synopsis

Abstract

Relationships are formulated in an attempt to explain the variation in the antitumour activity and toxicity of a series of diacridines. Three types of conformation are considered, these being relevant to the three types of double intercalation of DNA. The CNDO/2 method, with the incorporation of symmetry adapted orbitals, is used to obtain electron reactivity indices. Significant correlations are presented between the biological activities and the electronic and steric indices employed.

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