QSAR approach to understand the antitumour activity of organotins

✍ Scribed by R. Barbieri

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 623 KB
• Volume: 191
• Category: Article
• ISSN: 0020-1693
• DOI: 10.1016/s0020-1693(00)93468-6

✦ Synopsis

The activity of a series of diorganotin (IV) salts and complexes against murine leukaemia P388 (log(T/C)) is correlated to the lipophilicity (log P) of the organic radicals bound to the metal, as well as of radicals plus ligands in thiolato complexes. Compounds R&ha&, the related 0x0 and hydroxo derivatives, complexes R,SnX,.L, and R,SnL,4 (L being ligands with N and 0 donor atoms), and compounds with S-Sri bonds, R,Sn(SR') and R,Sn(SR'),, seem to originate three congeneric series, described by parabolic functions log(T/C) versus log P, the latter estimated for the organic radicals in R,Sn'". Compounds R,Sn(SR') yield an additional parabolic function, where log P concerns both R and SR'.