Interpretation of confidence intervals for median effective dose estimates
β Scribed by Mark S. Kaiser
- Book ID
- 112087809
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 765 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0730-7268
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
An important issue in dose finding is whether a further dose increment leads to a relevant increase in efficacy. Clinical efficacy should not be considered by point zero null hypotheses. Instead, shifted hypotheses for the difference or the ratio can be used. Because the a priori definition of a rel
## Abstract Parametric bootstrap methods for the construction of confidence intervals for the effective dose at level Ξ±(EDΞ±) under the probit model for the doseβresponse relationship are investigated. The standard maximum likelihood confidence intervals and percentile, centered percentile, studenti