International renal-cell cancer study. IV. Occupation

✍ Scribed by Jack S. Mandel; Joseph K. McLaughlin; Brigitte Schlehofer; Anders Mellemgaard; Uwe Helmert; Per Lindblad; Margaret McCredie; Hans-Olov Adami

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 607 KB
• Volume: 61
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910610503

✦ Synopsis

The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter populationbased case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found with employment in the blast-furnace or the coke-oven industry [relative risk (RR), I .7; 95% confidence interval (Cl), I. 1-2.71, the iron and steel industry (RR, I .6; 95% CI, 1.2-2.2) and exposure to asbestos (RR, I .4; 95% CI, I. I-1.8). cadmium (RR, 2.0; 95% CI, I .O-3.9), dry-cleaning solvents (RR, 1.4; 95% CI, 1.1-1.7), gasoline (RR, 1.6; 95% CI, 1.2-2.0) and other petroleum products (RR, I .6; 95% CI, I .3-2. I). Asbestos,

petroleum products and dry-cleaning solvents appear to merit further investigation, in view of the relationship between risk and duration of employment or exposure and after adjustment for confounding. There was a negative association between RCC and education, but it was not consistent across all centers. Overall, the results of our multicenter case-control study suggest that occupation may be more important in the etiology of RCC than indicated by earlier studies.