Internal reactions in the Grignard-complex containing compounds with alkoxy-groups: Part II. Cyclic acetals

✍ Scribed by C. Blomberg; A. D. Vreugdenhil; T. J. Homsma

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 270 KB
• Volume: 82
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19630820407

✦ Synopsis

Abstract

If one molar equivalent of 2‐methyl‐, 2‐ethyl‐ or 2‐n‐propyl‐1,3‐dioxolane is used for the preparation of Grignard‐reagents in benzene, the five‐membered hetero‐ring is opened with formation of a magnesium halide 2‐alkoxyethan‐1‐olate.

The steric and electronic effects of the alkyl groups of the Grignard‐reagent and those of the dioxolane molecule are discussed.