## Abstract We probe the role of free heme in the interactions between sickle cell hemoglobin (HbS) molecules in simulated physiological solutions: polymerization of deoxyβHbS is the primary pathogenic event of sickle cell anemia, and HbS releases heme after autoxidation more readily than normal ad
Intermolecular interactions of oxygenated sickle hemoglobin molecules in cells and cell-free solutions
β Scribed by Lindstrom, T.R.; Koenig, S.H.; Boussios, T.; Bertles, J.F.
- Book ID
- 118517315
- Publisher
- Biophysical Society
- Year
- 1976
- Tongue
- English
- Weight
- 735 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0006-3495
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
It has long been known that a simple hard particle model quantitatively explains the osmotic properties of monomeric hemoglobin near its isoelectric point. However, we find that a hard particle model is not consistent with the osmotic properties of polymerized hemoglobin and that substantial soft re
Pulse oximetry is a noninvasive method of measuring oxyhemoglobin saturation. The validity of pulse oximetry in sickle cell disease (SCD) has been questioned. We evaluated pulse oximetry, arterial blood gas analysis, and co-oximetry in patients with SCD, and we assessed the effect of dyshemoglobin a