Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton’s tyrosine kinase
✍ Scribed by Henrik Hansson; Michael P Okoh; C.I.Edvard Smith; Mauno Vihinen; Torleif Härd
- Book ID
- 117102661
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 93 KB
- Volume
- 489
- Category
- Article
- ISSN
- 0014-5793
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X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter
Bruton's tyrosine kinase (BTK) plays an important role in B cell development. Deletion of C-terminal14 amino acids of the SH3 domain of BTK results in X-linked a g ammaglobulinemia ( X U ) , an inherited disease. We report here on the stability and folding of SH3 domain of BTK. Peptides correspondin