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Both proline-rich sequences in the TH region of Bruton’s tyrosine kinase stabilize intermolecular interactions with the SH3 domain

✍ Scribed by Henrik Hansson; C.I.Edvard Smith; Torleif Härd


Book ID
117103540
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
196 KB
Volume
508
Category
Article
ISSN
0014-5793

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✍ Himatkumar V. Patel; Shiou-Ru Tzeng; Chen-Yee Liao; Shi-Han Chen; Jya-Wei Cheng 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB

X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter