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Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: Relationship between plasma concentrations and clinical parameters

✍ Scribed by R.L. Poorter; G.J. Peters; P.J.M. Bakker; C.W. Taat; D.M.J.Biermans-van Lecuwe; G. Codacci-Pisanelli; P. Noordhuis; J. Oosting; C.H.N. Veenhof

Book ID
116166369
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
639 KB
Volume
31
Category
Article
ISSN
0959-8049

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✍ Enrique Aranda; AndrΓ©s Cervantes; Javier Dorta; Esperanza Blanco; Carlos FernΓ‘nd πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 419 KB πŸ‘ 2 views

Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer