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Interleukins 1, 4 and 6 induce the colony formation of human bone marrow B lineage cells

✍ Scribed by Kimberley McGinnes; Christopher J. Paige

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
513 KB
Volume
21
Category
Article
ISSN
0014-2980

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✦ Synopsis

An agar-based, B cell colony assay (McGinnes, K. et al., Blood 1990. 76: 896) has been used to study the influence of known cytokines on the growth of B lineage colonies initiated by cells from normal, human bone marrow samples. We demonstrate that a combination of interleukin (IL) 1, IL4 and IL6 act directly to promote the generation of plaque-forming colonies. IL6 was shown to act at a late stage of colony formation, which is consistent with its role in the induction of immunoglobulin secretion from mature B cells. In contrast, IL 1 and IL4 were required at earlier stages in the formation of colonies containing cells which secrete immunoglobulin.

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