Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus
✍ Scribed by Sophie Hillion; Soizic Garaud; Valérie Devauchelle; Anne Bordron; Christian Berthou; Pierre Youinou; Christophe Jamin
- Book ID
- 108782145
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 600 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0019-2805
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Polyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL
## Abstract ## Objective Toll‐like receptors (TLRs) are pattern‐associated receptors in innate immunity that may be involved in the recognition of self antigens and the production of pathogenic autoantibodies. This study was undertaken to examine the expression and function of various TLRs in subp