Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas
β Scribed by Shunji Miki; Masayuki Iwano; Yoshitsugu Miki; Masahiro Yamamoto; Bo Tang; Kiyoshi Yokokawa; Takao Sonoda; Toshio Hirano; Tadamitsu Kishimoto
- Book ID
- 115922023
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 589 KB
- Volume
- 250
- Category
- Article
- ISSN
- 0014-5793
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Interleukin (IL)-6 is reported to function as a growth factor for renal and prostatic carcinomas. We conducted the present study to define the role of IL-6 in the growth of normal and neoplastic urothelial cells. Human bladder carcinoma cell lines (253J, RT4 and T24) and primary cultured human uroth
## Abstract Interleukinβ6 (ILβ6) is produced at high levels by renal cell carcinoma cell lines. The molecular mechanisms involved in its possible role as an autocrine growth factor were investigated. ILβ6 and ILβ6 receptor expression was investigated in 8 renal cell carcinoma (RCC) cell lines. The