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Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

✍ Scribed by Bernhard T Baune, Carsten Konrad, Dominik Grotegerd, Thomas Suslow, Eva Birosova, Patricia Ohrmann, Jochen Bauer, Volker Arolt, Walter Heindel, Katharina Domschke, Sonja Schöning, Astrid V Rauch, Christina Uhlmann, Harald Kugel, Udo Dannlowski

Book ID
119907440
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
288 KB
Volume
9
Category
Article
ISSN
1742-2094

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## Abstract Interleukin (IL)‐6 is a pleiotropic cytokine whose production by astrocytes in the CNS of transgenic mice (termed GF‐IL6) causes neuroinflammation and neurodegeneration. The binding of IL‐6 to its receptor (IL6R) triggers gp130‐mediated activation of STAT1 and STAT3 as well as SHP2 phos