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Interleukin (IL)-6 and IL-1β act synergistically within the brain to induce sickness behavior and fever in rats

✍ Scribed by Lois M. Harden; Irné du Plessis; Stephen Poole; Helen P. Laburn


Book ID
116276133
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
688 KB
Volume
22
Category
Article
ISSN
0889-1591

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## Interleukin -1␤ (IL-1␤) induces anorexia, fever, sleep changes, and neuroendocrine alterations when administered into the brain. Here, we investigated the regulation of the IL-1␤ system (ligand, receptors, receptor accessory protein, and receptor antagonist), tumor necrosis factor-␣ (TNF-␣), tr