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Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling

✍ Scribed by Cardoso, B A; Martins, L R; Santos, C I; Nadler, L M; Boussiotis, V A; Cardoso, A A; Barata, J T


Book ID
109886534
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
221 KB
Volume
23
Category
Article
ISSN
0887-6924

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This study found that phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling was activated in human T-cell lymphotropic virus type I (HTLV-1)-infected leukemia cells. Rapamycin (1-100 nM, 48 h), the inhibitor of mTOR and its analog RAD001 (1-100 nM, 48 h)-induced gro