Interleukin 4 inhibits the proliferation and promotes the maturation of human leukemic early B cells
✍ Scribed by Fateh Ouaaz; Franz Mentz; M. Djavad Mossalayi; Christian Schmitt; Ariane Michel; Patrice Debre; Jean-Jaques Guillosson; Hélène Merle-Beral; Michel Arock
- Book ID
- 114791748
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 515 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0902-4441
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We analyzed the effects of interleukin 2 (IL2) and IL4 isolated and in association on the specific response of human B cells triggered by trinitrophenylated polyacrylamide beads (TNP-PAA). IL2 induced an increase (more than 10 times) in the number of hapten-binding cells [detected by a rosette-formi
The activity of purified interleukin 2 (IL2), obtained by the recombinant DNA technology, on the proliferative response of human B cells stimulated with low concentrations of anti-p antibody was investigated. Recombinant IL 2 was capable of augmenting the proliferative response of anti-p-activated B