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Interleukin-3 and granulocyte-macrophage colony-stimulating factor in combination: Clinical implication

✍ Scribed by Frisch, Jürgen ;Ganser, Arnold ;Hoelzer, Dieter ;Brugger, Wolfram ;Kanz, Lothar ;Mertelsmann, Roland ;Schulz, Gregor

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
379 KB
Volume
20
Category
Article
ISSN
0098-1532

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✦ Synopsis

The multilineage hematopoietic effects of IL-3 appear to be most important for its clinical use comprising especially leucocyte and platelet responses. This was demonstrated to be dose dependent characterising doses of 250 to 500 micrograms/m2/day subcutaneously as hematopoietic effective and well tolerable. Since preclinical data suggest synergism between IL-3 and GM-CSF hematopoietic effects of their sequential administration were evaluated in 15 patients with preserved hematopoietic function. An enhanced stimulation of megakaryopoiesis combined with more pronounced stimulation of granulopoiesis than IL-3 alone could be demonstrated. The cytokine combination of IL-3 and GM-CSF was thus used during chemotherapy induced myelosuppression. Data indicates beyond the known amelioration of myelosuppression by GM-CSF additional chances to enhance platelet recovery which can be of important clinical impact.

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