Eosinophilia associated with adult t-cell leukemia: Role of interleukin 5 and granulocyte-macrophage colony-stimulating factor

✍ Scribed by Ogata, Masao; Ogata, Yuko; Kohno, Kazuhiro; Uno, Noritaka; Ohno, Eiji; Ohtsuka, Eiichi; Saburi, Yoshio; Kamberi, Perparim; Nasu, Masaru; Kikuchi, Hiroshi

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 29 KB
• Volume: 59
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199811)59:3<242::aid-ajh11>3.0.co;2-o

✦ Synopsis

To clarify the mechanism of eosinophilia in adult T-cell leukemia (ATL), we studied three ATL patients having marked eosinophilia. Eosinophil-predominant colony-stimulating activity was detected in the serum of one patient and in the conditioned media (CM) from cultured ATL cells from two patients. Soluble interleukin 5 (IL-5), but no interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), was detected in sera from all patients. On the other hand, GM-CSF was produced in vitro by ATL cells from all cases, whereas detectable IL-3 and IL-5 was produced by cells from only one, suggesting that in the other two cases, the serum IL-5 was produced by the normal reacting lymphocytes. The fact that no patient showed marked neutrophilia supports the possibility that IL-5 may have a leading role in the development of eosinophilia, with GM-CSF produced by ATL cells playing a complementary role. Am.