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Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

✍ Scribed by Giovanni Monteleone; Francesco Pallone; Thomas T. Macdonald

Book ID
116401125
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
245 KB
Volume
20
Category
Article
ISSN
1359-6101

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## Abstract ## Objective Interleukin‐21 (IL‐21) is a T cell–derived cytokine that modulates T cell, B cell, and natural killer cell responses. In this study, the effects of blocking IL‐21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL‐21 contributes to their