Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia
β Scribed by R. Berger; O.A. Bernard
- Book ID
- 116821585
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 220 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0369-8114
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## Abstract Most chromosomal translocations observed in Tβcell acute lymphoblastic leukemia (TβALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the __TLX3__ (also known as __HOX11L2__) gene has been shown to be associated with a cryptic t(5;14)(
## Abstract __MLL__ (also known as __ALLβ1, HTRX__, or __HRX__) gene translocations are among the most common chromosomal abnormalities recognized in both Bβlineage acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, __MLL__ gene rearrangements are uncommon in Tβcell ALL.