𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia

✍ Scribed by Xin Ying Su; Maryvonne Busson; Véronique Della Valle; Paola Ballerini; Nicole Dastugue; Pascaline Talmant; Adolfo A. Ferrando; Dominique Baudry-Bluteau; Serge Romana; Roland Berger; Olivier A. Bernard

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
141 KB
Volume
41
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Most chromosomal translocations observed in T‐cell acute lymphoblastic leukemia (T‐ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T‐ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T‐ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CTIP2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T‐ALL is strongly associated with the presence of genomic rearrangements. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

ABL1 rearrangements in T-Cell acute lymp
ABL1 rearrangements in T-Cell acute lymphoblastic leukemia
✍ Anne Hagemeijer; Carlos Graux 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis

M-BCR rearrangement in a case of T-cell
M-BCR rearrangement in a case of T-cell childhood acute lymphoblastic leukemia
✍ Silva, Maria Luiza Macedo; Fernandez, Teresa de Souza; de Souza, Maria Helena Or 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB 👁 2 views

of a de novo Ph in T-cell acute leukemia. So this case could be the first de novo T-cell childhood ALL showing the expression of p210 protein associated with a very aggressive clinical evolution.