Soluble interleukin-2 receptor (sll-2R) levels were quantitated in the seum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and degenerative joint disease (DJD). A sandwich immunoassay, employing two monoclonal antiodies against distinct epitopes on the lL-2R, was utilized for mea
Interleukin-2 Levels are Elevated in the Bone Marrow Serum of Patients with Mutilans-Type Rheumatoid Arthritis
โ Scribed by T. Kuroda; N. Tanabe; M. Sakatsume; S. Nozawa; T. Mitsuka; H. Ishikawa; C. T. Tohyama; K. Nakazono; A. Murasawa; M. Nakano; F. Gejyo
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 79 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0770-3198
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In a previous study, we used an enzyme-linked immunosorbent assay to measure soluble human interleukin-2 receptors (IL3R), and found that when activated lymphocytes produce cell-associated IL-2R, they also release a soluble form of IL3R into culture supernatants in vitro. Soluble IL-2R have also bee
Objective. Bone marrow stromal cell antigen I (BST-1) is a novel glycosyl phosphatidylinositolanchored ectoenzyme, which is overexpressed on bone marrow stromal and synovial cell lines derived from patients with rheumatoid arthritis (RA). To investigate the pathophysiologic roles of BST-I in RA, we