Stimulation of T cells by the T-cell receptor (TCR)/CD3 complex results in interleukin-2 (IL-2) synthesis and surface expression of the IL-2 receptor (IL-2R), which in turn drive T-cell proliferation. However, the significance of the requirement of IL-2 in driving T-cell proliferation, when TCR stim
Interleukin 2: Its role in the proliferation of neoplastic T and B cells
β Scribed by Dr B. Lowenberg; I. P. Touw
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 505 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0022-3417
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Peripheral blood T cells from a patient with Tβcell chronic lymphocytic leukemia (TβCLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukinβ2 (ILβ2). The TβCLL cells also proliferated in response to 12β__O_
The activity of purified interleukin 2 (IL2), obtained by the recombinant DNA technology, on the proliferative response of human B cells stimulated with low concentrations of anti-p antibody was investigated. Recombinant IL 2 was capable of augmenting the proliferative response of anti-p-activated B
## Role of CD40 antigen and interleukin-2 in T cell-dependent human B lymphocyte growth" In the present study, we examined the participation of CD40 ligand (L)-CD40 interaction in T cell-dependent B cell responses. To this end, purified B lymphocytes were cultured over irradiated CD4+ cloned T cel