Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
✍ Scribed by Maurus de la Rosa; Sascha Rutz; Heike Dorninger; Alexander Scheffold
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 195 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Although the phenotypic and regulatory properties of the CD4^+^CD25^+^ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4^+^CD25^+^ Treg population includes the recognition of a broad spectrum of human TCR CDR
## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut