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Interleukin-2 inhibits the GABA-induced Cl- current in identified Aplysia neurons

โœ Scribed by Dr. M. Sawada; N. Hara; M. Ichinose

Book ID
102386089
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
440 KB
Volume
33
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

The effects of extracellularly applied recombinant human interleukin-2 (rhIL-2) on the y-aminobutyric acid (GABA)-induced C1-current recorded from identified neurons (R9 and R12) of Aplysia kurodui were investigated with conventional voltage-clamp and pressure ejection techniques. Bath-applied rhIL-2 (10-40 U/ml) reduced the GABA-induced current in the neurons without affecting resting membrane conductance and the holding current. The suppressing effect of rhIL-2 on the current was completely reversible. Heat-inactivated rhIL-2 was without effect. These results suggest that the immunomodulator IL-2 can modulate the GABA-induced response in the nervous system.

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