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Interleukin 2-independent stimulation of rabbit chondrocyte collagenase and prostaglandin E2 production by an interleukin 1-like factor

✍ Scribed by Vlasta Evěquoz; Florence Bettens; Flemming Kristensen; Ulrich Trechsel; Beda M. Stadler; Jean-Michel Dayer; Alain L. de Weck; Herbert Fleisch


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
671 KB
Volume
14
Category
Article
ISSN
0014-2980

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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I