Interleukin-1α and tumor necrosis factor α synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts
✍ Scribed by Takemine Mino; Eiji Sugiyama; Hirofumi Taki; Arihiko Kuroda; Naohiro Yamashita; Muneharu Maruyama; Masashi Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 768 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0004-3591
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Monocyte/macrophage polypeptides (monokines) alter the properties of synovial cells. This interaction could explain some of the properties of the inflamed synovium in rheumatic disease. Only recently has it been possible to test the action of purified monokines on the target synovial cells. We repor
## Objective: To investigate the effects of the antiinflammatory cytokines interleukin-4 (il-4), il-10, and il-13 on tumor necrosis factor alpha (tnfalpha)-induced prostaglandin e2 (pge2) release in the cellular signaling cascade on human osteoarthritis (oa) synovial fibroblasts. ## Methods: Huma