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Interleukin-1B-enhancing genotypes are associated with increased risk of gastric cancer and its precursors

✍ Scribed by Emad M. El-Omar; Wong-Ho M. Chow; Kenneth E. McColl; Joseph F. Fraumeni; Charles S. Rabkin

Book ID
119425920
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
175 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract p21^Cip1^ and p27^Kip1^ are cyclin‐dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. Reduced protein expression of p21^Cip1^ and p27^Kip1^ was frequently observed in a subset of cancers, including breast cancer. In this study, we hypothesiz