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Interleukin-1 Represses COLIA1 Promoter Activity in Calvarial Bones of Transgenic ColCAT Mice In Vitro and In Vivo

✍ Scribed by John R. Harrison; Lisa M. Kleinert; Penny L. Kelly; Paul H. Krebsbach; Charles Woody; Stephen Clark; David W. Rowe; Alexander C. Lichtler; Barbara E. Kream


Book ID
111486353
Publisher
American Society for Bone and Mineral Research
Year
1998
Tongue
English
Weight
178 KB
Volume
13
Category
Article
ISSN
0884-0431

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Recently, it has been found that osteoclasts are induced and activated by osteoblastic cells through expression of receptor activator NF-kB ligand (RANKL), and that soluble recombinant RANKL, with M-CSF, can replace the need for osteoblastic cells in osteoclast formation. We exploited this opportuni