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Interleukin 1: a regulator of chondrocyte proliferation

✍ Scribed by Masahiro Iwamoto; Tatsuya Koike; Kazuhisa Nakashima; Katsuhiko Sato; Yukio Kato


Book ID
104177143
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
280 KB
Volume
21
Category
Article
ISSN
0165-2478

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## Abstract Interleukins 1Ξ± and 1Ξ² (IL‐1) are very potent signaling molecules that are expressed normally at low levels, but are induced rapidly in response to local or peripheral insults. IL‐1 coordinates systemic host defense responses to pathogens and to injury and not surprisingly it has simila

EFFECTS OF INTERLEUKIN-6 ON PROLIFERATIO
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Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr)