Interleukin 1: a regulator of chondrocyte proliferation
β Scribed by Masahiro Iwamoto; Tatsuya Koike; Kazuhisa Nakashima; Katsuhiko Sato; Yukio Kato
- Book ID
- 104177143
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 280 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0165-2478
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## Abstract Interleukins 1Ξ± and 1Ξ² (ILβ1) are very potent signaling molecules that are expressed normally at low levels, but are induced rapidly in response to local or peripheral insults. ILβ1 coordinates systemic host defense responses to pathogens and to injury and not surprisingly it has simila
Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr)