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Interindividual variability in the glucuronidation of zidovudine in human liver

โœ Scribed by PACIFICI, G


Book ID
122431597
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
93 KB
Volume
26
Category
Article
ISSN
1043-6618

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The effects of probenecid and paracetamol on zidovudine glucuronidation were investigated, in vitro, using human liver microsomal preparations. The presence of probenecid in the incubation medium significantly reduced the maximum reaction velocity for zidovudine glucuronide formation by more than 60