Amino acid (aa) mutations in the interferon-sensitivity determining region (ISDR) (aa position 237-276 of the nonstructural region 5A [NS5A] protein consisting of 447 amino acids) of hepatitis C virus (HCV) are related to increased interferon sensitivity and low viral load, but its mechanism has not
Interferon sensitivity-determining region of nonstructural region 5A of hepatitis C virus genotype 1b correlates with serum alanine aminotransferase levels in chronic infection
β Scribed by K. Yoshioka; H. Ito; K. Watanabe; M. Yano; M. Ishigami; T. Mizutani; Y. Sasaki; H. Goto
- Book ID
- 108885736
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 178 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1352-0504
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## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNAβdependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire
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