Long-term response to interferon alpha is unrelated to“interferon sensitivity determining region” variability in patients with chronic hepatitis C virus-1b infection
✍ Scribed by Giovanni Squadrito; Maria Elena Orlando; Irene Cacciola; Maria Grazia Rumi; Marco Artini; Antonio Picciotto; Oreste Loiacono; Rocco Siciliano; Massimo Levrero; Giovanni Raimondo
- Book ID
- 118569076
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 490 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0168-8278
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## Abstract The interferon sensitivity‐determining region (ISDR) is useful as a predictive marker of the response to interferon (IFN) therapy for chronic hepatitis patients with a Japan‐specific subtype (J‐type) of hepatitis C virus (HCV) genotype 1b. This marker is not useful for predicting respon
## Abstract The interferon sensitivity‐determining region (ISDR) is thought to be inhibited by the double‐stranded RNA‐dependent protein kinase (PKR). Several studies have reported a relationship between the ISDR and interferon (IFN) responsiveness. However, this relationship is controversial. The