𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons

✍ Scribed by Jieliang Li; Shuxian Hu; Lin Zhou; Li Ye; Xu Wang; Jie Ho; Wenzhe Ho

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
411 KB
Volume
59
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Herpes simplex virus Type I (HSV‐1) is a neurotropic virus that is capable of infecting not only neurons, but also microglia and astrocytes and can establish latent infection in the central nervous system (CNS). We investigated whether IFN lambda (IFN‐λ), a newly identified member of IFN family, has the ability to inhibit HSV‐1 infection of primary human astrocytes and neurons. Both astrocytes and neurons were found to be highly susceptible to HSV‐1 infection. However, upon IFN‐λ treatment, HSV‐1 replication in both astrocytes and neurons was significantly suppressed, which was evidenced by the reduced expression of HSV‐1 DNA and proteins. This IFN‐λ‐mediated action on HSV‐1 could be partially neutralized by antibody to IFN‐λ receptor. Investigation of the mechanisms showed that IFN‐λ treatment of astrocytes and neurons resulted in the upregulation of endogenous IFN‐α/β and several IFN‐stimulated genes (ISGs). To block IFN‐α/β receptor by a specific antibody could compromise the IFN‐λ actions on HSV‐1 inhibition and ISG induction. In addition, IFN‐λ treatment induced the expression of IFN regulatory factors (IRFs) in astrocytes and neurons. Furthermore, IFN‐λ treatment of astrocytes and neurons resulted in the suppression of suppressor of cytokine signaling 1 (SOCS‐1), a key negative regulator of IFN pathway. These data suggest that IFN‐λ possesses the anti‐HSV‐1 function by promoting Type I IFN‐mediated innate antiviral immune response in the CNS cells. © 2010 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Activation of Toll-like receptors inhibi
Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells
✍ Yu Zhou; Li Ye; Qi Wan; Lin Zhou; Xu Wang; Jieliang Li; Shuxian Hu; Dunjin Zhou; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB

## Abstract Toll‐like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)‐mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2‐N and CHP‐212 cells) express TLRs and mount type I IFN‐mediated i

Correlates of human herpes virus-8 and h
Correlates of human herpes virus-8 and herpes simplex virus type 2 infections in Northern Cameroon
✍ A. Volpi; L. Sarmati; B. Suligoi; M. Montano; G. Rezza; M. Andreoni 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB

## Abstract The association between sexual activity and human herpes virus‐8 (HHV‐8) infection has been established, but the mode of acquisition is still unclear. Blood samples from 238 individuals from Northern Cameroon were tested to evaluate the incidence of herpes simplex virus‐2 (HSV‐2), human

Successful treatment of aciclovir and fo
Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1
✍ Anne-Sophie Lascaux; Eric Caumes; Claire Deback; Giovanna Melica; Dominique Chal 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

## Abstract Aciclovir (ACV)‐resistant __Herpes simplex virus__ type‐2 (HSV‐2) infections are observed commonly in patients also infected with HIV‐1. The use of foscarnet (FOS) in these patients may also lead to resistance. This situation can become a difficult therapeutic challenge. Four cases of p

Retracted: Curcumin (diferuloylmethane)
Retracted: Curcumin (diferuloylmethane) inhibits constitutive active NF-κB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
✍ Mariko Tomita; Hirochika Kawakami; Jun-nosuke Uchihara; Taeko Okudaira; Masato M 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 378 KB

## Abstract Retraction: The following article has been retracted through agreement between the first author and several coauthors, the journal Editor‐in‐Chief, Peter Lichter, and John Wiley & Sons, Ltd.: Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y,