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Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1

✍ Scribed by Anne-Sophie Lascaux; Eric Caumes; Claire Deback; Giovanna Melica; Dominique Challine; Henri Agut; Yves Lévy

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
204 KB
Volume
84
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Aciclovir (ACV)‐resistant Herpes simplex virus type‐2 (HSV‐2) infections are observed commonly in patients also infected with HIV‐1. The use of foscarnet (FOS) in these patients may also lead to resistance. This situation can become a difficult therapeutic challenge. Four cases of patients infected with HIV and with mucocutaneous HSV‐2 resistant to ACV and FOS are reported. These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions. J. Med. Virol. 84:194–197, 2012. © 2011 Wiley Periodicals, Inc.

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