Interferon for treatment of breakthrough infection with hepatitis B virus mutants developing during long-term lamivudine therapy
โ Scribed by Fumitaka Suzuki; Akihito Tsubota; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
- Publisher
- Springer Japan
- Year
- 2002
- Tongue
- English
- Weight
- 265 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0944-1174
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Treatment of hepatitis B virus (HBV) with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif of DNA polymerase, has been reported. We report