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Interferon action and chromosome 21 trisomy

✍ Scribed by Leonard E. Maroun

Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
219 KB
Volume
86
Category
Article
ISSN
0022-5193

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πŸ“œ SIMILAR VOLUMES

Interferon Action and Chromosome 21 Tris
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A hypothesis relating interferon action and the chromosome 21 trisomy genotype and phenotype was presented in this journal in 1980. Since that time a number of additional genes involved in interferon action have been mapped to the distal Down Syndrome region of chromosome 21 and a growing literature

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Origin of the extra chromosome in trisomy 21
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Of 61 families of children with trisomy 21, polymorphism of chromosome 21 elucidating the origin of the extra chromosome was found in 42. Nondisjunction was of paternal origin in 8 cases (19.04%) and the anomaly occurred with equal frequency during the first and second meiotic divisions. Maternal no