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Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

✍ Scribed by Tobias Schilling; Astrid Kairat; Gerry Melino; Peter H. Krammer; Wolfgang Stremmel; Moshe Oren; Martina Müller

Book ID
116300065
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
678 KB
Volume
394
Category
Article
ISSN
0006-291X

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## Abstract A mutation in the tumor suppressor __p53__ gene resulting in an Arg→Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. To determine the significance of this mutation in an in vivo exp