## Abstract Deregulation of insulinβlike growth factorβ1 receptor (IGFβ1R) and focal adhesion kinase (FAK) signaling pathways plays an important role in cancer cell proliferation and metastasis. In pancreatic cancer cells, the crosstalk and compensatory mechanisms between these two pathways reduce
Interference of the IGF system as a strategy to inhibit breast cancer growth
β Scribed by Carlos L. Arteaga
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 632 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Biologic evidence suggests substantial effect of insulinβlike growth factor (IGF)βI in mammary cell carcinogenesis. However, controversy remains regarding the association between circulating IGFβI levels and the risk of premenopausal breast cancer in epidemiologic studies. In addition,
Cancers have a formidahle capacity to develop resistance to a large and diverse array of chemical, biologic, and physical anti-neoplastic agents. This can be largely traced to the instability of the tumor cell genome, and the resultant ability of tumor cell populations to generate phenotypic variant