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Interference of bcl-2 with intercellular control of carcinogenesis

✍ Scribed by Juliane M. Jürgensmeier; Georg Bauer

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
297 KB
Volume
71
Category
Article
ISSN
0020-7136

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✦ Synopsis

Induction of apoptosis in transformed fibroblasts by surrounding normal cells has been discussed as a potent early control step in carcinogenesis. According to this hypothesis, tumor progression should require resistance of transformed cells against this TGF-b-triggered control mechanism. Here we show that Bcl-2, a protein involved in inhibition of apoptosis, can protect transformed cells from induction of apoptotis by surrounding cells. Rather than acting on the transformation process itself, Bcl-2 may thus represent an efficient modulator of carcinogenesis at an intercellular level.

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