✦ LIBER ✦

Interactions of sulfonylureas with plasma proteins

✍ Scribed by Par-Lin Hsu; K. H. Joseph; Louis A. Luzzi

Book ID: 102408863
Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 399 KB
Volume: 63
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600630416

No coin nor oath required. For personal study only.

✦ Synopsis

expressed as micrograms per milliliter, uersus time in hours showed that the disappearance of I from plasma was biphasic.

The half-life for the terminal phase, as estimated graphically from the data between 6 and 24 hr after drug administration, was 6.2 hr. The combined results from these, investigations showed that the GLC method could be used for: (a) evaluating the pharmacokinetics, (b) evaluating drug availability from various dosage formulations, and (c) selecting an optimum dosage regimen for I administration to humans.

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