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Interactions of N-cyclopropylmethyl(−)-6β-acetylthionormorphine with μ-, κ-, δ- and σ-opioid receptors

✍ Scribed by Takayanagi, Issei; Koike, Katsuo; Satoh, Mitsutoshi


Book ID
123211220
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
246 KB
Volume
22
Category
Article
ISSN
0306-3623

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The design and synthesis of 10-oxo derivative of N-cyclopropylmethyl-(-)-613-acetylthio dihydronormorphine (4) are described. The result of pharmacological assays indicate that compound 4 acts as a tt-opioid receptor antagonist and K-opioid receptor agonist which is suggested to be more potent analg