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Interaction of newly synthesized N-cyclopropylmethyl derivatives of (−)-6β-acetylthionormorphine with opioid receptors

✍ Scribed by Takayanagi, I.; Goromaru, N.; Koike, K.; Konno, F.; Mori, T.; Yoshida, M.; Kanematsu, K.

Book ID
123533356
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
535 KB
Volume
21
Category
Article
ISSN
0306-3623

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The design and synthesis of 10-oxo derivative of N-cyclopropylmethyl-(-)-613-acetylthio dihydronormorphine (4) are described. The result of pharmacological assays indicate that compound 4 acts as a tt-opioid receptor antagonist and K-opioid receptor agonist which is suggested to be more potent analg