Data on the binding of imipramine, desipramine, and 3-chlorodesmethylimipramine to plasma proteins have been obtained over a wide range of ligand concentration using a modified equilibrium dialysis technique. Plasma proteins other than albumin do not appreciably contribute to complex formation with
β¦ LIBER β¦
Interactions of drugs with proteins II: Experimental methods, treatment of experimental data, and thermodynamics of binding reactions of thymoleptic drugs and model dyes
β Scribed by H. J. Weder; M. H. Bickel
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 774 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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We have developed BLEEP biomolecular ligand energy evaluation . Ε½ . protocol , an atomic level potential of mean force PMF describing proteinαligand interactions. Here, we present four tests designed to assess different attributes of BLEEP. Calculating the energy of a small hydrogen-bonded complex