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Interactions between dietary flavonoids and 2,3,7,8-tetrachlorodibenzo-p-dioxin on cytochromes P450 activity in a human intestinal model (Caco-2 cells)

✍ Scribed by Thérèse Sergent; Isabelle Dupont; Luc Pussemier; Yvan Larondelle; Yves-Jacques Schneider


Book ID
119379403
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
87 KB
Volume
172
Category
Article
ISSN
0378-4274

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We analyzed the function of a DNA domain located upstream of the cytochrome P4501A1 gene in wild-type (Hepa lclc7) mouse hepatoma cells and in high-activityvariant (HAV) cells that overtranscribe the gene in response to the inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Transfection experiments