The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o
✦ LIBER ✦
Interactions between CCAAT enhancer binding protein δ and estrogen receptor α control insulin-like growth factor I (igf1) and estrogen receptor-dependent gene expression in osteoblasts
✍ Scribed by Weizhong Chang; Macarena Parra; Michael Centrella; Thomas L. McCarthy
- Book ID
- 116506962
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 619 KB
- Volume
- 345
- Category
- Article
- ISSN
- 0378-1119
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## Abstract We examined the relationship between signal transduction and the expression of insulin‐like growth factor I (IGF‐I), IGF‐I receptor level, and IGF binding proteins (IGFBPs) in murine clonal osteoblastic MC3T3‐E1 cells. 12–O‐Tetradecanoylphorbol‐13‐acetate (TPA), an activator of protein