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Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro

✍ Scribed by D. McCotter; H.W. van den Berg; M. Boylan; B. McKibben


Book ID
116123396
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
978 KB
Volume
99
Category
Article
ISSN
0304-3835

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The insulin-like growth factors (IGFs) have been implicated in the growth regulation of human breast cancer. Since the lCFs are associated with specific binding proteins (ICFBPs) which may modulate receptor/ligand interactions, production of IGFBPs by breast cancer cells could alter their IGF-depend