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Interaction with DNA as a cytotoxicity factor of a novel glycoside derivative of indolocarbazole

✍ Scribed by D. N. Kalyuzhnyi; V. V. Tatarskii; F. S. Bondarev; I. L. Plikhtyak; T. D. Miniker; S. Ya. Mel’nik; A. A. Shtil’; O. F. Borisova

Book ID
111469784
Publisher
SP MAIK Nauka/Interperiodica
Year
2006
Tongue
English
Weight
157 KB
Volume
411
Category
Article
ISSN
1607-6729

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## Abstract __Novel indolocarbazole derivative 12‐(__α__‐L‐arabinopyranosyl)indolo[2,3‐__α__]pyrrolo[3,4‐__c__]carbazole‐5,7‐dione (AIC) demonstrated high potency (at submicromolar concentrations) against the NCI panel of human tumor cell lines and transplanted tumors in vivo. In search of tentativ