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Novel Antitumor L-Arabinose Derivative of Indolocarbazole with High Affinity to DNA

✍ Scribed by Dmitry N. Kaluzhny; Victor V. Tatarskiy Jr.; Lyubov G. Dezhenkova; Irina L. Plikhtyak; Tatyana D. Miniker; Anna K. Shchyolkina; Sergey A. Strel'tsov; Ghermes G. Chilov; Fedor N. Novikov; Irina Yu. Kubasova; Zoya S. Smirnova; Stalina Ya. Mel'nik; Mikhail A. Livshits; Olga F. Borisova; Alexander A. Shtil

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
399 KB
Volume
4
Category
Article
ISSN
1860-7179

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Novel Antitumor L-Arabinose Derivative o
Novel Antitumor L-Arabinose Derivative of Indolocarbazole with High Affinity to DNA
✍ Dmitry N. Kaluzhny; Victor V. Tatarskiy Jr.; Lyubov G. Dezhenkova; Irina L. Plik 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 399 KB

## Abstract __Novel indolocarbazole derivative 12‐(__α__‐L‐arabinopyranosyl)indolo[2,3‐__α__]pyrrolo[3,4‐__c__]carbazole‐5,7‐dione (AIC) demonstrated high potency (at submicromolar concentrations) against the NCI panel of human tumor cell lines and transplanted tumors in vivo. In search of tentativ