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Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

✍ Scribed by Cayrol, Corinne; Ducommun, Bernard


Book ID
110061661
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
429 KB
Volume
17
Category
Article
ISSN
0950-9232

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## Abstract p21, a universal inhibitor of mammalian cyclin‐dependent kinases (CDK), regulates cell cycle progression by forming various distinct protein complexes with cyclins, CDKs, and the proliferating cell nuclear antigen. We have overexpressed recombinant human p21 in __E. coli__ and purified